Tuesday, September 6, 2016

Researcher Interview: Dr. John Agnew

Dr. Agnew is a faculty member at Walden University and a reviewer for JSBHS

1. Please briefly describe your current research.
Most recently, my research has attempted to understand behavioral aspects of autism and develop behavioral interventions that may improve the quality of life for children with autism and their families. As part of this research, I have been involved with studies of repetitive behaviors in autism spectrum disorders; biomarkers, such as salivary cortisol; and behavioral interventions, such as therapeutic horseback riding. In this last study, 116 adolescents with autism spectrum disorder were enrolled in a randomized control trial, half receiving the horseback riding intervention and half receiving a small group intervention at the same facility that did not involve horseback riding. The primary outcome measure was aberrant behaviors, but we also assessed social measures and communication abilities. The results of this study indicated that 10 weeks of therapeutic horseback riding significantly improved aberrant behaviors and some social measures in the treatment group compared with the control group. Further analysis suggested that the improvements in the aberrant behaviors remained for a period of months after the treatment ended. These results suggest that therapeutic horseback riding may be an effective behavioral treatment for children and adolescents with autism spectrum disorders. This work has been published as:

Gabriels, R. L., Pan, Z., Dechant, B., Agnew, J. A., Brim, N., & Mesibov, G. (2015). Randomized controlled trial of therapeutic horseback riding in children and adolescents with Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 54(7), 541 - 549. doi: 10.1016/j.jaac.2015.04.007


2 How did you come to be in this area of study?
Prior to becoming involved in autism research, my research in graduate school involved functional magnetic resonance imaging studies of developmental dyslexia. While at Georgetown University, I developed a behavioral task in which subjects moved their thumb in time with a visual stimulus while monitoring their brain activity using functional magnetic resonance imaging. By comparing the neural activity between subjects with dyslexia and neurotypical controls, I was able to show differences in the patterns of brain activity between the two groups.


3. What do like best about doing research?
What I like about research and about neuroscience in general, is that there is so much about the brain that we do not yet know or understand. This field is a very active one, and new findings are published every day. These may be at the chemical level, identifying chemicals that are important for brain communication and development; at the level of brain anatomy, where researchers have just recently discovered nearly 100 brain regions that were previously unknown; or at the clinical level, such as my research into behavioral therapies for autism spectrum disorders. Research is what helps expand our understanding of these systems and conditions and, by doing research, we can help others.


4. What do you dislike the most about doing research?
While research can be very rewarding, research also can be very frustrating. Most biomedical research in the United States is funded by the NIH, and grant funding levels have fallen dramatically in recent years. That means that less research can be accomplished and fewer students will be able to fund their graduate education or early careers in research science. That is concerning both for research today and research in the coming years, as people leave science for other fields. Beyond funding concerns, research can be frustrating because experiments do not always result in what you expected to find. But, that is the process of science. Even if the experiment does not work out, it does often generate new questions to address in the next experiment.

5. Advice for new researchers who would like to be published?
Be detailed. Be persistent. Taking those in order, science is a very precise field. You need to understand the question you are asking and the measurements you are making. The history of science is littered with experimental results that seemed to point to one conclusion, but actually said something very different once the question was better understood. So be detailed and specific about what you are asking and what you are measuring. Second, be persistent. It takes a long time and many attempts to have your grant funded or your journal article accepted. Personally, I have never been successful on the first attempt at either. Just review the feedback you receive and implement that into your next attempt. The feedback is meant as constructive criticism to help you clarify your thinking and your writing. I will add one more piece of advice for publishing your manuscript. When you have your research completed and analyzed, start to think about where you might want to publish. Each journal has a focus, so you need to identify how you want to present your research and find a journal that publishes about that topic and to the audience you think will benefit from your study. Then, read several articles from that journal and work to match the style as much as you can. Do they follow APA format, MLA format, or some other format for the manuscript and references? How do they use headings and tables and figures? Complying with the style guidelines of the journal is a good first step to show the editor and the reviewers that you have paid attention to the details and that they should take your work seriously.


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